Drug Interactions Database

Comprehensive interaction checker for Fenbendazole tablets with clinical management guidelines and severity assessments

🔍 Check Interactions ⚠️ Contraindications

Drug Interaction Checker

Search for specific drug interactions and get clinical management recommendations

All Interactions
High Severity
Moderate Severity
Low Severity

Cimetidine

High Severity
Drug Class H2 Receptor Antagonist
Mechanism Inhibits hepatic metabolism of Fenbendazole
Effect Increased Fenbendazole plasma concentrations

Clinical Management

Management
Reduce Fenbendazole dose by 25-50% or avoid combination
Monitoring
Monitor for increased adverse effects
Alternatives
Famotidine, Ranitidine (if available)

Ketoconazole

High Severity
Drug Class Antifungal - Azole
Mechanism Inhibits CYP450 enzymes affecting Fenbendazole metabolism
Effect Significantly increased Fenbendazole levels

Clinical Management

Management
Avoid concurrent use or reduce Fenbendazole dose
Monitoring
Monitor liver function and adverse events
Alternatives
Fluconazole (lower interaction risk)

Antacids (Aluminum, Magnesium)

Moderate Severity
Drug Class Antacid
Mechanism Reduced gastrointestinal absorption
Effect Decreased Fenbendazole bioavailability

Clinical Management

Management
Administer Fenbendazole 2 hours before or after antacids
Monitoring
Monitor therapeutic efficacy
Alternatives
H2 blockers, PPIs (with timing adjustment)

Rifampin

Moderate Severity
Drug Class Antibiotic - Rifamycin
Mechanism Induces hepatic enzymes increasing Fenbendazole metabolism
Effect Decreased Fenbendazole plasma concentrations

Clinical Management

Management
May need to increase Fenbendazole dose
Monitoring
Monitor therapeutic response
Alternatives
Other antibiotics with less enzyme induction

Warfarin

Moderate Severity
Drug Class Anticoagulant
Mechanism Potential displacement from protein binding
Effect Increased anticoagulant effect

Clinical Management

Management
Monitor INR closely, adjust warfarin dose as needed
Monitoring
INR monitoring every 2-3 days initially
Alternatives
Direct oral anticoagulants (with caution)

Phenytoin

Moderate Severity
Drug Class Anticonvulsant
Mechanism Enzyme induction affecting Fenbendazole metabolism
Effect Decreased Fenbendazole effectiveness

Clinical Management

Management
Monitor therapeutic response, consider dose adjustment
Monitoring
Clinical monitoring of parasitic infection
Alternatives
Newer anticonvulsants with less enzyme induction

Carbamazepine

Moderate Severity
Drug Class Anticonvulsant
Mechanism Enzyme induction increasing Fenbendazole clearance
Effect Reduced Fenbendazole plasma levels

Clinical Management

Management
Consider increasing Fenbendazole dose
Monitoring
Monitor therapeutic efficacy
Alternatives
Levetiracetam, Lamotrigine

Oral Contraceptives

Low Severity
Drug Class Hormonal Contraceptive
Mechanism Potential reduction in contraceptive efficacy
Effect Decreased contraceptive effectiveness

Clinical Management

Management
Use additional contraceptive methods
Monitoring
Patient counseling on backup contraception
Alternatives
Non-hormonal contraceptive methods

Contraindications & Cautions

Important contraindications and precautions for Fenbendazole therapy

Hypersensitivity to Benzimidazoles

Severity: Absolute Contraindication

Description: History of allergic reaction to Fenbendazole or other benzimidazole derivatives

Recommended Action:

Contraindicated - use alternative anthelmintic

Pregnancy (First Trimester)

Severity: Relative Contraindication

Description: Limited safety data in early pregnancy

Recommended Action:

Avoid unless benefits clearly outweigh risks

Severe Hepatic Impairment

Severity: Relative Contraindication

Description: Impaired metabolism may lead to drug accumulation

Recommended Action:

Use with caution, dose reduction may be required

Pre-existing Blood Disorders

Severity: Relative Contraindication

Description: May exacerbate hematological conditions

Recommended Action:

Use with caution, monitor blood counts closely

General Precautions

  • Always obtain complete medication history before prescribing
  • Monitor patients with pre-existing liver disease closely
  • Use caution in elderly patients and those with multiple comorbidities
  • Consider drug interactions in polypharmacy patients
  • Pregnant and lactating women should use only if clearly indicated

For prescription and export purposes only. Use under medical supervision. Not intended for self-medication. Information for educational purposes. Export subject to local regulations.

© 2026 Fenbendazole Pharma. All Rights Reserved.
For prescription and export purposes only. Not intended for self-medication. Export subject to local regulations.